Detection of BCR-ABL Fusion mRNA Using Reverse Transcriptase Loop-mediated Isothermal Amplification
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
RT-PCR is commonly used for the detection of Bcr-Abl fusion transcripts in patients diagnosed with chronic myelogenous leukemia, CML. Two fusion transcripts predominate in CML, Br-Abl e13a2 and e14a2. They have developed reverse transcriptase isothermal loop-mediated amplification (RT-LAMP) assays to detect these two fusion transcripts along with the normal Bcr transcript.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- DOE Contract Number:
- W-7405-ENG-48; AC52-07NA27344
- OSTI ID:
- 1034502
- Report Number(s):
- LLNL--TR-520096
- Country of Publication:
- United States
- Language:
- English
Similar Records
Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia
RT-PCR is a more accurate diagnostic tool for detection of BCR-ABL rearrangement
Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
Journal Article
·
Thu Jun 01 00:00:00 EDT 1989
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:5299687
RT-PCR is a more accurate diagnostic tool for detection of BCR-ABL rearrangement
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· American Journal of Human Genetics
·
OSTI ID:133611
Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
Journal Article
·
Thu Oct 25 00:00:00 EDT 2012
· Cell
·
OSTI ID:1039450