skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Anti-influenza M2e antibody

Patent ·
OSTI ID:1034171

Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-06NA25396
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Number(s):
8,080,244
Application Number:
12/592,241
OSTI ID:
1034171
Country of Publication:
United States
Language:
English

References (3)

Construction of miniantibodies for the in vivo study of human autoimmune diseases in animal models journal January 2007
Fine specificity and sequence of antibodies directed against the ectodomain of matrix protein 2 of influenza A virus☆ journal July 2006
Effects of humanization by variable domain resurfacing on the antiviral activity of a single-chain antibody against respiratory syncytial virus journal April 1999