Compact intermediates in RNA folding
Journal Article
·
· Biophysics
- JHU
Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transition, which coincides with the assembly of helical domains, depends on RNA sequence and counterions. It determines the specificity of the folding pathways and the magnitude of the free energy barriers to the ensuing search for the native conformation. By coupling helix assembly with nascent tertiary interactions, compact folding intermediates in RNA also play a crucial role in ligand binding and RNA-protein recognition.
- Research Organization:
- Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
- Sponsoring Organization:
- USDOE Office of Science (SC)
- OSTI ID:
- 1031363
- Journal Information:
- Biophysics, Journal Name: Biophysics Journal Issue: 6 Vol. 39
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
RNA Tertiary Interactions Mediate Native Collapse of a Bacterial Group I Ribozyme
Cooperative Tertiary Interaction Network Guides RNA Folding
Extended Structures in RNA Folding Intermediates Are Due to Nonnative Interactions Rather than Electrostatic Repulsion
Journal Article
·
Tue Jul 13 00:00:00 EDT 2010
· J. Mol. Biol.
·
OSTI ID:1008593
Cooperative Tertiary Interaction Network Guides RNA Folding
Journal Article
·
Mon Apr 08 00:00:00 EDT 2013
· Cell
·
OSTI ID:1039067
Extended Structures in RNA Folding Intermediates Are Due to Nonnative Interactions Rather than Electrostatic Repulsion
Journal Article
·
Tue May 25 00:00:00 EDT 2010
· J. Mol. Biol.
·
OSTI ID:1002396