Skewed X-inactivation in a tumor tissue from a female patient with leiomyomatosis
- Nagasaki Univ. School of Medicine, Nagasaki (Japan); and others
Leiomyomatosis (multiple leiomyomas) is characterized by benign smooth muscle cell proliferations in the esophagus, tracheobronchial tree, and female genital tract. At least 3 genetically different hereditary leiomyomatoses have been identified. Among them, an X-linked leiomyomatosis is often associated with an Alport syndrome-like nephropathy. It has remained obscure whether the leiomyomata occur monoclonally or polyclonally. The clonality of various malignancies has been examined by analysis of X-inactivation patterns in female patients heterozygous for polymorphic alleles of X-linked genes. We examined the clonality of a leiomyoma in a female patient by a polymerase chain reaction (PCR)-based X-inactivation assay. 6 refs., 1 fig.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 102899
- Journal Information:
- American Journal of Medical Genetics, Vol. 57, Issue 4; Other Information: PBD: 17 Jul 1995
- Country of Publication:
- United States
- Language:
- English
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