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Title: Influence of strontium on structure, sintering and biodegradation behaviour of CaO-MgO-SrO-SiO2-P2O5-CaF2 glasses

Abstract

The present study investigates the influence of SrO on structure, apatite forming ability, physico-chemical degradation and sintering behaviour of melt-quenched bioactive glasses with composition: mol.% (36.07 – x) CaO – x SrO - 19.24 MgO – 5.61 P2O5 – 38.49 SiO2 – 0.59 CaF2, where x varies between 0 – 10. The detailed structural analysis of glasses has been made by infra red spectroscopy (FTIR) and magic angle spinning-nuclear magnetic resonance spectroscopy (MAS-NMR). Silicon was predominantly present as Q2 (Si) species while phosphorus was found in orthophosphate type environment in all the investigated glasses. The apatite forming ability of glasses was investigated by immersion of glass powders in simulated body fluid (SBF) for time durations varying between 1 h – 7 days. While increasing Sr2+/Ca2+ ratio in glasses did not affect the structure of glasses significantly, their apatite forming ability was decreased considerably. Further, physico-chemical degradation of glasses has been studied in accordance with ISO 10993-14 “Biological evaluation of medical devices – Part 14: Identification and quantification of degradation products from ceramics” in Tris HCl and citric acid buffer and the possible implications of ion release profile from glasses in different solutions has been discussed. The addition of strontium inmore » glasses led to a 7-fold decrease in chemical degradation of glasses in Tris-HCl. The sintering of glass powders rendered glass-ceramics (GCs) with varying degree of crystallinity and good flexural strength (98-131 MPa) where the mechanical properties depend on the nature and amount of crystalline phases present in GCs.« less

Authors:
; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1026590
Report Number(s):
PNNL-SA-81007
TRN: US201120%%919
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Acta Biomaterialia, 7(11):4071-4080
Additional Journal Information:
Journal Volume: 7; Journal Issue: 11
Country of Publication:
United States
Language:
English
Subject:
58 GEOSCIENCES; APATITES; BIODEGRADATION; BODY FLUIDS; BUFFERS; CERAMICS; CITRIC ACID; EVALUATION; FLEXURAL STRENGTH; GLASS; MAGNETIC RESONANCE; MECHANICAL PROPERTIES; PHOSPHORUS; SILICON; SINTERING; SPECTROSCOPY; STRONTIUM

Citation Formats

Goel, Ashutosh, Rajagopal, Raghu R., and Ferreira, Jose M. Influence of strontium on structure, sintering and biodegradation behaviour of CaO-MgO-SrO-SiO2-P2O5-CaF2 glasses. United States: N. p., 2011. Web. doi:10.1016/j.actbio.2011.06.047.
Goel, Ashutosh, Rajagopal, Raghu R., & Ferreira, Jose M. Influence of strontium on structure, sintering and biodegradation behaviour of CaO-MgO-SrO-SiO2-P2O5-CaF2 glasses. United States. doi:10.1016/j.actbio.2011.06.047.
Goel, Ashutosh, Rajagopal, Raghu R., and Ferreira, Jose M. Tue . "Influence of strontium on structure, sintering and biodegradation behaviour of CaO-MgO-SrO-SiO2-P2O5-CaF2 glasses". United States. doi:10.1016/j.actbio.2011.06.047.
@article{osti_1026590,
title = {Influence of strontium on structure, sintering and biodegradation behaviour of CaO-MgO-SrO-SiO2-P2O5-CaF2 glasses},
author = {Goel, Ashutosh and Rajagopal, Raghu R. and Ferreira, Jose M.},
abstractNote = {The present study investigates the influence of SrO on structure, apatite forming ability, physico-chemical degradation and sintering behaviour of melt-quenched bioactive glasses with composition: mol.% (36.07 – x) CaO – x SrO - 19.24 MgO – 5.61 P2O5 – 38.49 SiO2 – 0.59 CaF2, where x varies between 0 – 10. The detailed structural analysis of glasses has been made by infra red spectroscopy (FTIR) and magic angle spinning-nuclear magnetic resonance spectroscopy (MAS-NMR). Silicon was predominantly present as Q2 (Si) species while phosphorus was found in orthophosphate type environment in all the investigated glasses. The apatite forming ability of glasses was investigated by immersion of glass powders in simulated body fluid (SBF) for time durations varying between 1 h – 7 days. While increasing Sr2+/Ca2+ ratio in glasses did not affect the structure of glasses significantly, their apatite forming ability was decreased considerably. Further, physico-chemical degradation of glasses has been studied in accordance with ISO 10993-14 “Biological evaluation of medical devices – Part 14: Identification and quantification of degradation products from ceramics” in Tris HCl and citric acid buffer and the possible implications of ion release profile from glasses in different solutions has been discussed. The addition of strontium in glasses led to a 7-fold decrease in chemical degradation of glasses in Tris-HCl. The sintering of glass powders rendered glass-ceramics (GCs) with varying degree of crystallinity and good flexural strength (98-131 MPa) where the mechanical properties depend on the nature and amount of crystalline phases present in GCs.},
doi = {10.1016/j.actbio.2011.06.047},
journal = {Acta Biomaterialia, 7(11):4071-4080},
number = 11,
volume = 7,
place = {United States},
year = {2011},
month = {11}
}