Structure of Plasmodium falciparum ADP-ribosylation factor 1

Journal Article · Mon Sep 26 04:00:00 EDT 2011 · Acta Crystallogr. F

DOI:https://doi.org/10.1107/S1744309110036997· OSTI ID:1025631

Cook, William J; Smith, Craig D; Senkovich, Olga; Holder, Anthony A; Chattopadhyay, Debasish ^[1]

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1. UAB

Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 {angstrom} resolution and is compared with the structures of mammalian ARF1s.

• Research Organization: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
• Sponsoring Organization: DOE - BASIC ENERGY SCIENCES
• OSTI ID: 1025631
• Journal Information: Acta Crystallogr. F, Journal Name: Acta Crystallogr. F Journal Issue: (11) ; 11, 2010 Vol. 66; ISSN 1744-3091
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
CRYSTAL STRUCTURE
MALARIA
PATHOGENESIS
PLASMODIUM
PROTEINS
RESOLUTION