Does the cortical bone resorption rate change due to ⁹⁰Sr-radiation exposure? Analysis of data from Techa Riverside residents

Journal Article · Mon Aug 01 00:00:00 EDT 2011 · Radiation and Environmental Biophysics

DOI:https://doi.org/10.1007/s00411-011-0363-z· OSTI ID:1021831

Tolstykh, E I; Shagina, N B; Degteva, M O; Anspaugh, L R; Napier, Bruce A

The Mayak Production Association released large amounts of ⁹⁰Sr into the Techa River (Southern Urals, Russia) with peak amounts in 1950-1951. Techa Riverside residents ingested an average of about 3,000 kBq of ⁹⁰Sr. The ⁹⁰Sr-body burden of approximately 15,000 individuals has been measured in the Urals Research Center for Radiation Medicine in 1974-1997 with use of a special whole-body counter (WBC). Strontium-90 had mainly deposited in the cortical part of the skeleton by 25 years following intake, and ⁹⁰Sr elimination occurs as a result of cortical bone resorption. The effect of ⁹⁰Sr-radiation exposure on the rate of cortical bone resorption was studied. Data on 2,022 WBC measurements were selected for 207 adult persons, who were measured three or more times before they were 50-55 years old. The individual-resorption rates were calculated with the rate of strontium recirculation evaluated as 0.0018 year^-1. Individual absorbed doses in red bone marrow (RBM) and bone surface (BS) were also calculated. Statistically significant negative relationships of cortical bone resorption rate were discovered related to ⁹⁰Sr-body burden and dose absorbed in the RBM or the BS. The response appears to have a threshold of about 1.5-Gy RBM dose. The radiation induced decrease in bone resorption rate may not be significant in terms of health. However, a decrease in bone remodeling rate can be among several causes of an increased level of degenerative dystrophic bone pathology in exposed persons.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1021831
• Report Number(s): PNNL-SA-79525; HU2006300; TRN: US201117%%404
• Journal Information: Radiation and Environmental Biophysics, Vol. 50, Issue 3; ISSN 0301-634X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ADULTS
BONE MARROW
MEDICINE
PATHOLOGY
PRODUCTION
RADIATION DOSES
RADIATIONS
SKELETON
STRONTIUM
STRONTIUM 90
TECHA RIVER
URALS
WHOLE-BODY COUNTERS
bone remodeling
radiation dose
Techa River