Response to Comments on "A Bacterium That Can Grow Using Arsenic Instead of Phosphorus"

Wolfe-Simon, F; Blum, J S; Kulp, T R; Gordon, G W; Hoeft, S E; Pett-Ridge, J; Stolz, J F; Webb, S M; Weber, P K; Davies, P W; Anbar, A D; Oremland, R S

doi:10.1126/science.1202098

Response to Comments on "A Bacterium That Can Grow Using Arsenic Instead of Phosphorus"

Journal Article · Mon Mar 07 04:00:00 EST 2011 · Science

DOI:https://doi.org/10.1126/science.1202098· OSTI ID:1021547

Wolfe-Simon, F; Blum, J S; Kulp, T R; Gordon, G W; Hoeft, S E; Pett-Ridge, J; Stolz, J F; Webb, S M; Weber, P K; Davies, P W; Anbar, A D; Oremland, R S

Concerns have been raised about our recent study describing a bacterium that can grow using arsenic (As) instead of phosphorus (P). Our data suggested that As could act as a substitute for P in major biomolecules in this organism. Although the issues raised are of investigative interest, we contend that they do not invalidate our conclusions. We argue that while no single line of evidence we presented was sufficient to support our interpretation of the data, taken as an entire dataset we find no plausible alternative to our conclusions. Here we reply to the critiques and provide additional arguments supporting the assessment of the data we reported.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

OSTI ID:: 1021547

Report Number(s):: LLNL-JRNL-472592

Journal Information:: Science, Journal Name: Science Journal Issue: 6034 Vol. 332; ISSN 0193-4511; ISSN SCEHDK

Country of Publication:: United States

Language:: English

References (24)

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