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Title: Dinosaur Peptides Suggest Mechanisms of Protein Survival

Abstract

Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few acidic amino acids. Four peptides mapped to collagen regions crucial for cell-collagen interactions and tissue development. Dinosaur peptides were not represented in more exposed parts of the collagen fibril or regions mediating intermolecular cross-linking. Thus functionally significant regions of collagen fibrils that are physically shielded within the fibril may be preferentially preserved in fossils. These results show empirically that structure-function relationships at the molecular level could contribute to selective preservation in fossilized vertebrate remains across geological time, suggest a 'preservation motif', and bolster current concepts linking collagen structure to biological function. This non-random distribution supports the hypothesis that the peptides are produced by the extinct organisms and suggests a chemical mechanism for survival.

Authors:
; ; ; ; ;  [1];  [2];  [2];  [2];  [2];  [2]
  1. (Harvard-Med)
  2. (
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NSFOTHERNIH
OSTI Identifier:
1021193
Resource Type:
Journal Article
Journal Name:
PLoS One
Additional Journal Information:
Journal Volume: 6; Journal Issue: (6) ; 06, 2011
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; AMINO ACIDS; BIOLOGICAL FUNCTIONS; COLLAGEN; DISTRIBUTION; HYPOTHESIS; MOLECULAR MODELS; PEPTIDES; PRESERVATION; PROTEINS; VERTEBRATES

Citation Formats

San Antonio, James D., Schweitzer, Mary H., Jensen, Shane T., Kalluri, Raghu, Buckley, Michael, Orgel, Joseph P.R.O., IIT), NCSU), UPENN), Manchester), and Orthovita). Dinosaur Peptides Suggest Mechanisms of Protein Survival. United States: N. p., 2011. Web. doi:10.1371/journal.pone.0020381.
San Antonio, James D., Schweitzer, Mary H., Jensen, Shane T., Kalluri, Raghu, Buckley, Michael, Orgel, Joseph P.R.O., IIT), NCSU), UPENN), Manchester), & Orthovita). Dinosaur Peptides Suggest Mechanisms of Protein Survival. United States. doi:10.1371/journal.pone.0020381.
San Antonio, James D., Schweitzer, Mary H., Jensen, Shane T., Kalluri, Raghu, Buckley, Michael, Orgel, Joseph P.R.O., IIT), NCSU), UPENN), Manchester), and Orthovita). Fri . "Dinosaur Peptides Suggest Mechanisms of Protein Survival". United States. doi:10.1371/journal.pone.0020381.
@article{osti_1021193,
title = {Dinosaur Peptides Suggest Mechanisms of Protein Survival},
author = {San Antonio, James D. and Schweitzer, Mary H. and Jensen, Shane T. and Kalluri, Raghu and Buckley, Michael and Orgel, Joseph P.R.O. and IIT) and NCSU) and UPENN) and Manchester) and Orthovita)},
abstractNote = {Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few acidic amino acids. Four peptides mapped to collagen regions crucial for cell-collagen interactions and tissue development. Dinosaur peptides were not represented in more exposed parts of the collagen fibril or regions mediating intermolecular cross-linking. Thus functionally significant regions of collagen fibrils that are physically shielded within the fibril may be preferentially preserved in fossils. These results show empirically that structure-function relationships at the molecular level could contribute to selective preservation in fossilized vertebrate remains across geological time, suggest a 'preservation motif', and bolster current concepts linking collagen structure to biological function. This non-random distribution supports the hypothesis that the peptides are produced by the extinct organisms and suggests a chemical mechanism for survival.},
doi = {10.1371/journal.pone.0020381},
journal = {PLoS One},
number = (6) ; 06, 2011,
volume = 6,
place = {United States},
year = {2011},
month = {9}
}