Discovery and Characterization of the N-phenyl-N 0 -Naphthylurea Class of p38 Kinase Inhibitors
Journal Article
·
· Bioorganic and Medicinal Chemistry Letters
An effort aimed at exploring structural diversity in the N-pyrazole-N{prime}-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization of N-phenyl-N{prime}-naphthylureas. Examples of these compounds displayed excellent inhibition of TNF-{alpha} production in vitro, as well as efficacy in a mouse model of lipopolysaccharide induced endotoxemia. In addition, perspective is provided on the role of a sulfonamide functionality in defining inhibitor potency.
- Research Organization:
- Brookhaven National Laboratory (BNL) National Synchrotron Light Source
- Sponsoring Organization:
- DOE - OFFICE OF SCIENCE
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1019898
- Report Number(s):
- BNL--95744-2011-JA
- Journal Information:
- Bioorganic and Medicinal Chemistry Letters, Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Issue: 9 Vol. 19; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- English
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