Toxicologic evaluation of analytes from Tank 241-C-103
Westinghouse Hanford Company requested PNL to assemble a toxicology review panel (TRP) to evaluate analytical data compiled by WHC, and provide advice concerning potential health effects associated with exposure to tank-vapor constituents. The team`s objectives would be to (1) review procedures used for sampling vapors from tanks, (2) identify constituents in tank-vapor samples that could be related to symptoms reported by workers, (3) evaluate the toxicological implications of those constituents by comparison to establish toxicological databases, (4) provide advice for additional analytical efforts, and (5) support other activities as requested by WHC. The TRP represents a wide range of expertise, including toxicology, industrial hygiene, and occupational medicine. The TRP prepared a list of target analytes that chemists at the Oregon Graduate Institute/Sandia (OGI), Oak Ridge National Laboratory (ORNL), and PNL used to establish validated methods for quantitative analysis of head-space vapors from Tank 241-C-103. this list was used by the analytical laboratories to develop appropriate analytical methods for samples from Tank 241-C-103. Target compounds on the list included acetone, acetonitrile, ammonia, benzene, 1, 3-butadiene, butanal, n-butanol, hexane, 2-hexanone, methylene chloride, nitric oxide, nitrogen dioxide, nitrous oxide, dodecane, tridecane, propane nitrile, sulfur oxide, tributyl phosphate, and vinylidene chloride. The TRP considered constituent concentrations, current exposure limits, reliability of data relative to toxicity, consistency of the analytical data, and whether the material was carcinogenic or teratogenic. A final consideration in the analyte selection process was to include representative chemicals for each class of compounds found.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 10194648
- Report Number(s):
- PNL-10189; ON: DE95003175; TRN: 94:024064
- Resource Relation:
- Other Information: PBD: Nov 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
Waste tank safety program annual status report for FY 1993, Task 5: Toxicology and epidemiology
Waste tank vapor project: Vapor characterization of Tank 241-C-103: Data report for OVS samples collected from Sample Job 7b, Parts I and II, received 5/18/94 and 5/24/94
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HANFORD RESERVATION
OCCUPATIONAL SAFETY
ORGANIC COMPOUNDS
TOXICITY
AMMONIA
NITROGEN OXIDES
SULFUR OXIDES
CHEMICAL ANALYSIS
MEASURING METHODS
054000
560300
HEALTH AND SAFETY
CHEMICALS METABOLISM AND TOXICOLOGY