Results of heavy ion radiotherapy

Conference · Fri Apr 01 04:00:00 EST 1994

OSTI ID:10179402

Castro, J R ^[1]

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1. Lawrence Berkeley Lab., CA (United States). Life Sciences Div.

The potential of heavy ion therapy for clinical use in cancer therapy stems from the biological parameters of heavy charged particles, and their precise dose localization. Biologically, carbon, neon and other heavy ion beams (up to about silicon) are clinically useful in overcoming the radioresistance of hypoxic tumors, thus increasing biological effectiveness relative to low-LET x-ray or electron beams. Cells irradiated by heavy ions show less variation in cell-cycle related radiosensitivity and decreased repair of radiation injury. The physical parameters of these heavy charged particles allow precise delivery of high radiation doses to tumors while minimizing irradiation of normal tissues. Clinical use requires close interaction between radiation oncologists, medical physicists, accelerator physicists, engineers, computer scientists and radiation biologists.

• Research Organization: Lawrence Berkeley Lab., CA (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 10179402
• Report Number(s): LBL--35723; CONF-9403155--1; ON: DE94018197; CNN: Contract NIH-NCI CA19138
• Country of Publication: United States
• Language: English

Related Subjects

550603
62 RADIOLOGY AND NUCLEAR MEDICINE
EXTERNAL RADIATION IN THERAPY
HEAVY IONS
NEOPLASMS
RADIATION DOSES
RADIOTHERAPY
RBE
TUMOR CELLS