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Title: Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels

Abstract

A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.

Inventors:
 [1];  [1];  [2];  [3];  [2]
  1. Knoxville, TN
  2. Oak Ridge, TN
  3. Lancing, TN
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1016353
Patent Number(s):
7,909,973
Application Number:
US Patent Application 12/156,635
Assignee:
UT-Battelle, LLC (Wilmington, DE)
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Jacobson, Stephen C, Ramsey, J Michael, Culbertson, Christopher T, Whitten, William B, and Foote, Robert S. Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels. United States: N. p., 2011. Web.
Jacobson, Stephen C, Ramsey, J Michael, Culbertson, Christopher T, Whitten, William B, & Foote, Robert S. Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels. United States.
Jacobson, Stephen C, Ramsey, J Michael, Culbertson, Christopher T, Whitten, William B, and Foote, Robert S. Tue . "Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels". United States. https://www.osti.gov/servlets/purl/1016353.
@article{osti_1016353,
title = {Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels},
author = {Jacobson, Stephen C and Ramsey, J Michael and Culbertson, Christopher T and Whitten, William B and Foote, Robert S},
abstractNote = {A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {3}
}

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Works referenced in this record:

Electrokinetic Flow in a Narrow Cylindrical Capillary
journal, November 1965

  • Rice, C. L.; Whitehead, R.
  • The Journal of Physical Chemistry, Vol. 69, Issue 11
  • DOI: 10.1021/j100895a062

Development and analytical performance of tubular polymer membrane electrode-based carbon dioxide catheters
journal, April 1986

  • Opdycke, Walter N.; Meyerhoff, M. E.
  • Analytical Chemistry, Vol. 58, Issue 4
  • DOI: 10.1021/ac00295a062

Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)
journal, October 1998

  • Duffy, David C.; McDonald, J. Cooper; Schueller, Olivier J. A.
  • Analytical Chemistry, Vol. 70, Issue 23, p. 4974-4984
  • DOI: 10.1021/ac980656z