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The development of iodine-123-methyl-branched fatty acids and their applications in nuclear cardiology

Conference ·
OSTI ID:10162123
;  [1]; ;  [2];  [3];  [4];  [5];  [6]; ;  [7]
  1. Oak Ridge National Lab., TN (United States)
  2. Bonn Univ. (Germany). Inst. fuer Klinische und Experimentelle Nuklearmedizin
  3. University of Tennessee Medical Center, Knoxville, TN (United States). Dept. of Radiology
  4. Free Univ. Hospital, Brussels (Belgium). Nuclear Medicine Dept.
  5. Ulm Univ. (Germany). Sektion Nuklearmedizin
  6. Brookhaven National Lab., Upton, NY (United States)
  7. Free Univ. Hospital, Amsterdam (Netherlands). Cardiology Dept.
+ Show Author Affiliations
Continued Interest in the use of iodine-1 23-labeled fatty acids for myocardial Imaging results from observations from a variety of studies that in many types of cardiac disease, regional fatty acid myocardial uptake patterns are often different than regional distribution of flow tracers. These differences may reflect alterations in important parameters of metabolism which can be useful for patient management or therapeutic strategy decision making. In addition, use of iodine-I 23-labeled fatty acid distribution may represent a unique metabolic probe to relate some aspects of the metabolism of these substrates with the regional viability of cardiac tissue. The use of such viability markers could provide important prognostic information on myocardial salvage, helping to identify patients for revascularization or angioplasty. Clinical studies are currently in progress with the iodine-123-labeled 1 5-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) fatty acid analogue at several institutions. The goals of this paper are to discuss development of the concept of metabolic trapping of fatty acids, to briefly review development and evaluation of various radioiodinated methyl-branched fatty acids and to discuss recent patient studies with iodine-123 (BMIPP) using single photon emission computerized tomography (SPECT).
Research Organization:
Brookhaven National Lab., Upton, NY (United States)
Sponsoring Organization:
USDOE, Washington, DC (United States)
DOE Contract Number:
AC02-76CH00016; AC05-84OR21400
OSTI ID:
10162123
Report Number(s):
BNL--48712; CONF-9302119--1; ON: DE93014051; CNN: Grant CRG 900966
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703
550601
62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
CHEMICAL PREPARATION
HEART
IODINATION
IODINE 123
LABELLING
MONOCARBOXYLIC ACIDS
RADIOISOTOPE PRODUCTION
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
UNSEALED RADIONUCLIDES IN DIAGNOSTICS