Increased IMP dehydrogenase gene expression in solid tumor tissues and tumor cell lines
IMP dehydrogenase, a regulatory enzyme of guanine nucleotide biosynthesis, may play a role in cell proliferation and malignancy. To assess this possibility, we examined IMP dehydrogenase expression in a series of human solid tumor tissues and tumor cell lines in comparison with their normal counterparts. Increased IMP dehydrogenase gene expression was observed in brain tumors relative to normal brain tissue and in sarcoma cells relative to normal fibroblasts. Similarly, in several B- and T-lymphoid leukemia cell lines, elevated levels of IMP dehydrogenase mRNA and cellular enzyme were observed in comparison with the levels in peripheral blood lymphocytes. These results are consistent with an association between increased IMP dehydrogenase expression and either enhanced cell proliferation or malignant transformation.
- Research Organization:
- Argonne National Lab., IL (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 10148922
- Report Number(s):
- ANL/BIM/PP--74812; ON: DE94011495
- Country of Publication:
- United States
- Language:
- English
Similar Records
Regulation of IMP dehydrogenase gene expression by its end products, guanine nucleotides
Cell differentiation and altered IMP dehydrogenase expression induced in human T-lymphoblastoid leukemia cells by mycophenolic acid and tiazofurin
Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells
Journal Article
·
Thu Oct 31 23:00:00 EST 1991
· Molecular and Cellular Biology; (United States)
·
OSTI ID:5089854
Cell differentiation and altered IMP dehydrogenase expression induced in human T-lymphoblastoid leukemia cells by mycophenolic acid and tiazofurin
Journal Article
·
Wed Feb 28 23:00:00 EST 1990
· Experimental Cell Research; (United States)
·
OSTI ID:5378006
Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells
Journal Article
·
Sun May 01 00:00:00 EDT 1988
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6245000