[Experiments with radon and cigarette smoke]. Progress report

Technical Report · Thu Apr 01 04:00:00 EST 1993

DOI:https://doi.org/10.2172/10138606· OSTI ID:10138606

Moolgavkar, S H

Cancer models have been used for the analysis of incidence data in epidemiology and time to tumor data in experimental studies. The relevant quantities for the analyses of these data are the hazard function and the probability of tumor. We have begun to use these models for the analysis of data on intermediate lesions on the pathway to cancer. Such data are available in experimental carcinogenesis studies, in particular in initiation and promotion studies on the mouse skin and the rat liver. Typically, such data take the form of information on the number and size distribution of intermediate lesions as functions of the dose of the chemical agents applied and time on study. If, quantitative information on intermediate lesions on the pathway to lung cancer were to become available at some future date, the methods that we have developed for the analysis of initiation promotion experiments could easily be applied to the analysis of these lesion. The mathematical derivations here are couched in terms of a particular two-mutation model of carcinogenesis. Extension to models postulating more than two mutations is not always straightforward.

• Research Organization: Fred Hutchinson Cancer Research Center, Seattle, WA (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG06-88ER60657
• OSTI ID: 10138606
• Report Number(s): DOE/ER/60657--T1; ON: DE93010960
• Country of Publication: United States
• Language: English

Related Subjects

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560300
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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CHEMICALS METABOLISM AND TOXICOLOGY
DIFFERENTIAL EQUATIONS
GENE MUTATIONS
MAN
MATHEMATICAL MODELS
ONCOGENIC TRANSFORMATIONS
PROGRESS REPORT
RADON
TOBACCO SMOKES