Genetic variation in resistance to ionizing radiation. Progress report, January--July 1990
We proposed an investigation of genetically-determined individual differences in sensitivity to ionizing radiation. The model organism is Drosophila melanogaster. The gene coding for Cu, Zn superoxide dismutase (SOD) is the target locus, but the effects of variation in other components of the genome that modulate SOD levels are also taken into account. SOD scavenges oxygen radicals generated during exposure to ionizing radiation. It has been shown to protect against ionizing radiation damage to DNA, viruses, bacteria, mammalian cells, whole mice, and Drosophila. Two alleles, S and F, are commonly found in natural populations of D. melanogaster; in addition we have isolated from a natural population of ``null`` (CA1) mutant that yields only 3.5% of normal SOD activity. The S, F, and CA1 alleles provide an ideal model system to investigate SOD-dependent radioresistance, because each allele yields different levels of SOD, so that S > F >> CA1. The role of SOD levels in radioresistance are being investigated in a series of experiments that measure the somatic and germ-line effects of increasing doses of ionizing radiation. During the first seven months of funding we have completed a number of experiments and are proceeding with many others. We have made progress along all the research lines anticipated for the first year of this grant, as summarized in the following pages.
- Research Organization:
- California Univ., Irvine, CA (United States). Dept. of Ecology and Evolutionary Biology
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG03-88ER60713
- OSTI ID:
- 10116222
- Report Number(s):
- DOE/ER/60713-T2; ON: DE92007059
- Resource Relation:
- Other Information: PBD: [1990]
- Country of Publication:
- United States
- Language:
- English
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Genetic variation in resistance to ionizing radiation. Technical progress report, January--December 1991
Genetic variation in resistance to ionizing radiation
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DROSOPHILA
GENETIC RADIATION EFFECTS
PROGRESS REPORT
GENETIC VARIABILITY
IONIZING RADIATIONS
ENZYMES
RADICALS
BIOCHEMISTRY
OXYGEN
COPPER COMPOUNDS
ZINC COMPOUNDS
GENOTYPE
ENZYME ACTIVITY
MUTANTS
STERILITY
560152
550400
ANIMALS
GENETICS