Urine sample collection protocols for bioassay samples

Conference · Sun Nov 01 04:00:00 EST 1992

OSTI ID:10114414

MacLellan, J A; McFadden, K M

In vitro radiobioassay analyses are used to measure the amount of radioactive material excreted by personnel exposed to the potential intake of radioactive material. The analytical results are then used with various metabolic models to estimate the amount of radioactive material in the subject`s body and the original intake of radioactive material. Proper application of these metabolic models requires knowledge of the excretion period. It is normal practice to design the bioassay program based on a 24-hour excretion sample. The Hanford bioassay program simulates a total 24-hour urine excretion sample with urine collection periods lasting from one-half hour before retiring to one-half hour after rising on two consecutive days. Urine passed during the specified periods is collected in three 1-L bottles. Because the daily excretion volume given in Publication 23 of the International Commission on Radiological Protection (ICRP 1975, p. 354) for Reference Man is 1.4 L, it was proposed to use only two 1-L bottles as a cost-saving measure. This raised the broader question of what should be the design capacity of a 24-hour urine sample kit.

• Research Organization: Pacific Northwest Lab., Richland, WA (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 10114414
• Report Number(s): PNL-SA--21397; CONF-9211116--8; ON: DE93004838
• Country of Publication: United States
• Language: English

Related Subjects

054000
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
560101
61 RADIATION PROTECTION AND DOSIMETRY
BIOASSAY
DOSIMETRY
DOSIMETRY AND MONITORING
HEALTH AND SAFETY
PERSONNEL
QUALITATIVE CHEMICAL ANALYSIS
RADIOASSAY
STATISTICS
TRITIUM
URINE
VOLUME