Closure for milliliter scale bioreactor

Patent · Tue Dec 14 00:00:00 EST 2010

OSTI ID:1010278

Klein, David L ^[1]; Laidlaw, Robert D ^[2]; Andronaco, Gregory ^[1]; Boyer, Stephen G ^[3]

---

1. Palo Alto, CA
2. Albany, CA
3. Moss Beach, CA

A closure for a microreactor includes a cap that is configured to be inserted into a well of the microreactor. The cap, or at least a portion of the cap, is compliant so as to form a seal with the well when the cap is inserted. The cap includes an aperture that provides an airway between the inside of the well to the external environment when the cap is inserted into the well. A porous plug is inserted in the aperture, e.g., either directly or in tube that extends through the aperture. The porous plug permits gas within the well to pass through the aperture while preventing liquids from passing through to reduce evaporation and preventing microbes from passing through to provide a sterile environment. A one-way valve may also be used to help control the environment in the well.

• Research Organization: Gener 8 Inc
• Sponsoring Organization: USDOE
• DOE Contract Number: FG02-04ER83963
• Assignee: Pall Microreactor Technologies, Inc. (Mountain View, CA)
• Patent Number(s): 7,851,204
• Application Number: 11/450,855
• OSTI ID: 1010278
• Country of Publication: United States
• Language: English