Phase contrast imaging of cochlear soft tissue.
- X-Ray Science Division
A noninvasive technique to image soft tissue could expedite diagnosis and disease management in the auditory system. We propose inline phase contrast imaging with hard X-rays as a novel method that overcomes the limitations of conventional absorption radiography for imaging soft tissue. In this study, phase contrast imaging of mouse cochleae was performed at the Argonne National Laboratory Advanced Photon Source. The phase contrast tomographic reconstructions show soft tissue structures of the cochlea, including the inner pillar cells, the inner spiral sulcus, the tectorial membrane, the basilar membrane, and the Reissner's membrane. The results suggest that phase contrast X-ray imaging and tomographic techniques hold promise to noninvasively image cochlear structures at an unprecedented cellular level.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC); National Science Foundation (NSF)
- DOE Contract Number:
- DE-AC02-06CH11357
- OSTI ID:
- 1009371
- Report Number(s):
- ANL/XSD/CP-69437; TRN: US1101431
- Resource Relation:
- Conference: SPIE Medical Imaging Conference (SPIE 2011); Feb. 12, 2011 - Feb. 17, 2011; Lake Buena Vista, FL
- Country of Publication:
- United States
- Language:
- ENGLISH
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