Phase contrast imaging of cochlear soft tissue.

Conference · Sat Jan 01 04:00:00 EST 2011

DOI:https://doi.org/10.1117/12.882949· OSTI ID:1009371

Smith, S; Hwang, M; Rau, C; Fishman, A; Lee, W; Richter, C ^[1]

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1. X-Ray Science Division

A noninvasive technique to image soft tissue could expedite diagnosis and disease management in the auditory system. We propose inline phase contrast imaging with hard X-rays as a novel method that overcomes the limitations of conventional absorption radiography for imaging soft tissue. In this study, phase contrast imaging of mouse cochleae was performed at the Argonne National Laboratory Advanced Photon Source. The phase contrast tomographic reconstructions show soft tissue structures of the cochlea, including the inner pillar cells, the inner spiral sulcus, the tectorial membrane, the basilar membrane, and the Reissner's membrane. The results suggest that phase contrast X-ray imaging and tomographic techniques hold promise to noninvasively image cochlear structures at an unprecedented cellular level.

• Research Organization: Argonne National Laboratory (ANL)
• Sponsoring Organization: SC; NSF
• DOE Contract Number: AC02-06CH11357
• OSTI ID: 1009371
• Report Number(s): ANL/XSD/CP-69437
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

43 PARTICLE ACCELERATORS
ABSORPTION
ADVANCED PHOTON SOURCE
ANL
DIAGNOSIS
DISEASES
MANAGEMENT