No Evidence for a Low Linear Energy Transfer Adaptive Response in Irradiated RKO Cells
Journal Article
·
· Radiation Protection Dosimetry, 143(2-4):311-314
It has become increasingly evident from reports in the literature that there are many confounding factors that are capable of modulating radiation induced non-targeted responses such as the bystander effect and the adaptive response. In this paper we examine recent data that suggest that the observation of non-targeted responses may not be universally observable for differing radiation qualities. We have conducted a study of the adaptive response following low LET exposures for human colon carcinoma cells and failed to observe adaption for the endpoints of clonogenic survival or micronucleus formation.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1008228
- Report Number(s):
- PNNL-SA-70739; RPDODE; KP1602020; TRN: US201106%%339
- Journal Information:
- Radiation Protection Dosimetry, 143(2-4):311-314, Vol. 143, Issue 2-4; ISSN 0144-8420
- Country of Publication:
- United States
- Language:
- English
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