Biomolecular transport and separation in nanotubular networks.
- Sandia National Laboratories, Albuquerque, NM
Cell membranes are dynamic substrates that achieve a diverse array of functions through multi-scale reconfigurations. We explore the morphological changes that occur upon protein interaction to model membrane systems that induce deformation of their planar structure to yield nanotube assemblies. In the two examples shown in this report we will describe the use of membrane adhesion and particle trajectory to form lipid nanotubes via mechanical stretching, and protein adsorption onto domains and the induction of membrane curvature through steric pressure. Through this work the relationship between membrane bending rigidity, protein affinity, and line tension of phase separated structures were examined and their relationship in biological membranes explored.
- Research Organization:
- Sandia National Laboratories
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC04-94AL85000
- OSTI ID:
- 1008147
- Report Number(s):
- SAND2010-6473
- Country of Publication:
- United States
- Language:
- English
Similar Records
Membrane stiffness and myelin basic protein binding strength as molecular origin of multiple sclerosis