New Helical Foldamers: Heterogeneous Backbones with 1:2 and 2:1 [alpha]:[superscript beta]-Amino Acid Residue Patterns

Journal Article · Fri Oct 03 00:00:00 EDT 2008 · J. Am. Chem. Soc.

DOI:https://doi.org/10.1021/ja060281w· OSTI ID:1007704

Schmitt, Margaret A; Choi, SooHyuk; Guzei, Ilia A; Gellman, Samuel H ^[1]

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1. UW

Foldamers, oligomers with strong folding propensities, are subjects of growing interest because such compounds offer unique scaffolds for the development of molecular function. We report two new foldamer classes, oligopeptides with regular 1:2 or 2:1 patterns of {alpha}- and {beta}-amino acid residues. Two distinct helical conformations are detected via 2D NMR in methanol for each backbone. One of the helices for each backbone is characterized via X-ray crystallography.

• Research Organization: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
• Sponsoring Organization: USDOE
• OSTI ID: 1007704
• Journal Information: J. Am. Chem. Soc., Journal Name: J. Am. Chem. Soc. Journal Issue: (14) ; 02, 2006 Vol. 128; ISSN JACSAT; ISSN 0002-7863
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

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CRYSTALLOGRAPHY
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RESIDUES