Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
Journal Article
·
· Bioorg. Med. Chem. Lett.
- SPRI
A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the in-vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors.
- Research Organization:
- Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1007630
- Journal Information:
- Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Journal Issue: (22) ; 11, 2007 Vol. 17; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 2
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors
Journal Article
·
Tue Nov 19 23:00:00 EST 2013
· Bioorg. Med. Chem. Lett.
·
OSTI ID:1025622
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach
Journal Article
·
Fri Nov 01 00:00:00 EDT 2013
· Bioorganic and Medicinal Chemistry Letters
·
OSTI ID:1404959
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors
Journal Article
·
Fri Oct 01 00:00:00 EDT 2010
· Bioorg. Med. Chem. Lett.
·
OSTI ID:1007159