Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands
Journal Article
·
· Bioorg. Med. Chem. Lett.
- GSKNC
A series of estrogen receptor ligands based on a 3-alkyl naphthalene scaffold was synthesized using an intramolecular enolate-alkyne cycloaromatization as the key step. Several of these compounds bearing a C6-OH group were shown to be high affinity ligands. All compounds had similar ER{alpha} and ER{beta} binding affinity ranging from micromolar to low nanomolar.
- Research Organization:
- Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1007104
- Journal Information:
- Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Journal Issue: (18) ; 09, 2008 Vol. 18; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- ENGLISH
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