Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

Journal Article · Mon Apr 19 00:00:00 EDT 2010 · Nat. Struct. Mol. Biol.

DOI:https://doi.org/10.1038/nsmb.1404· OSTI ID:1006616

Huai, Q; Zhou, A; Lin, L; Mazar, A P; Parry, G C; Callahan, J; Shaw, D E; Furie, B; Furie, B C; Huang, M ^[1]

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1. Harvard-Med

The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.

• Research Organization: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
• Sponsoring Organization: USDOE
• OSTI ID: 1006616
• Journal Information: Nat. Struct. Mol. Biol., Journal Name: Nat. Struct. Mol. Biol. Journal Issue: (4) ; 04, 2008 Vol. 15; ISSN 1545-9993
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

60 APPLIED LIFE SCIENCES
COMPLEXES
CRYSTAL STRUCTURE
HUMAN POPULATIONS
LIGANDS
RECEPTORS
UROKINASE