Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-[beta] receptor promoter DNA

Journal Article · Fri Oct 08 00:00:00 EDT 2010 · Acta Crystallogr. F

DOI:https://doi.org/10.1107/S1744309109038007· OSTI ID:1006186

Agarkar, Vinod B; Babayeva, Nigar D; Rizzino, Angie; Tahirov, Tahir H

Ets proteins are transcription factors that activate or repress the expression of genes that are involved in various biological processes, including cellular proliferation, differentiation, development, transformation and apoptosis. Like other Ets-family members, Elf3 functions as a sequence-specific DNA-binding transcriptional factor. A mouse Elf3 C-terminal fragment (amino-acid residues 269-371) containing the DNA-binding domain has been crystallized in complex with mouse type II TGF-{beta} receptor promoter (TR-II) DNA. The crystals belonged to space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 42.66, b = 52, c = 99.78 {angstrom}, and diffracted to a resolution of 2.2 {angstrom}.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE
• OSTI ID: 1006186
• Journal Information: Acta Crystallogr. F, Vol. 65, Issue (12) ; 12, 2009; ISSN 1744-3091
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
APOPTOSIS
DNA
GENES
PROMOTERS
PROTEINS
RESIDUES
RESOLUTION
SPACE GROUPS
TRANSCRIPTION FACTORS
TRANSFORMATIONS