Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency
Journal Article
·
· Bioorg. Med. Chem. Lett.
Optimization of kinase selectivity for a set of benzothiophene MK2 inhibitors provided analogs with potencies of less than 500 nM in a cell based assay. The selectivity of the inhibitors can be rationalized by examination of X-ray crystal structures of inhibitors bound to MK2.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1006150
- Journal Information:
- Bioorg. Med. Chem. Lett., Vol. 19, Issue (16) ; 08, 2009; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- ENGLISH
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