Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui
Journal Article
·
· Antimicrob. Agents Ch.
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.
- Research Organization:
- Argonne National Laboratory (ANL)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1005979
- Journal Information:
- Antimicrob. Agents Ch., Journal Name: Antimicrob. Agents Ch. Journal Issue: (12) ; 12, 2009 Vol. 53; ISSN 0066-4804; ISSN AMACCQ
- Country of Publication:
- United States
- Language:
- ENGLISH
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