Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors
Journal Article
·
· Bioorg. Med. Chem. Lett.
A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of 4g showed a unique binding mode different from other well known JNK3 inhibitors.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1005841
- Journal Information:
- Bioorg. Med. Chem. Lett., Vol. 19, Issue (12) ; 06, 2009; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- ENGLISH
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