A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution
Crystal structures of A-form and B-form DNA duplexes containing 2'-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3'-endo pucker, illustrating that the replacement of electronegative oxygen at the 2'-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1005593
- Journal Information:
- Chem. Commun., Vol. 15, Issue 2009
- Country of Publication:
- United States
- Language:
- ENGLISH
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