Self-Control in Cocaine Addiction (440th Brookhaven Lecture)
- Ph.D., Medical Dept
A drug-addicted person may set a goal to abstain from taking drugs, yet soon afterwards he or she will ignore all warnings or reprimands, take an excessive amount of a drug, and possibly go much farther, such as trade in a car, or another valuable possession, for a couple of cocaine hits. This disadvantageous decision-making and drug- seeking behavior may continue despite catastrophic personal consequences -- for example, loss of job, health, or family -- even when the drug is no longer perceived as pleasurable. A series of brain-mapping studies and neuropsychological tests conducted at BNL has shown that people addicted to cocaine have an impaired ability to process rewards and exercise control, in a way that is directly linked to changes in the responsiveness in their prefrontal cortex, a part of the brain essential for advantageously monitoring and controlling one's own behavior. Goldstein will describe her research in this field, which was designed to test a theoretical model postulating that drug-addicted individuals disproportionately attribute value to their drug of choice -- at the expense of other potentially but no-longer-rewarding stimuli and at the same time, experience decreased ability to inhibit their drug use.
- Research Organization:
- BNL (Brookhaven National Laboratory (BNL), Upton, NY (United States))
- Sponsoring Organization:
- USDOE Office of Science (SC)
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1005226
- Report Number(s):
- BNL-83215-2008-CP
- Country of Publication:
- United States
- Language:
- English
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