Myofilament length dependent activation

Journal Article · Tue May 25 04:00:00 EDT 2010 · J. Mol. Cell. Cardiol.

DOI:https://doi.org/10.1016/j.yjmcc.2009.12.017· OSTI ID:1002388

de Tombe, Pieter P; Mateja, Ryan D; Tachampa, Kittipong; Mou, Younss Ait; Farman, Gerrie P; Irving, Thomas C ^[1]

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1. IIT

The Frank-Starling law of the heart describes the interrelationship between end-diastolic volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis. The main cellular mechanism that underlies this phenomenon is an increase in the responsiveness of cardiac myofilaments to activating Ca{sup 2+} ions at a longer sarcomere length, commonly referred to as myofilament length-dependent activation. This review focuses on what molecular mechanisms may underlie myofilament length dependency. Specifically, the roles of inter-filament spacing, thick and thin filament based regulation, as well as sarcomeric regulatory proteins are discussed. Although the 'Frank-Starling law of the heart' constitutes a fundamental cardiac property that has been appreciated for well over a century, it is still not known in muscle how the contractile apparatus transduces the information concerning sarcomere length to modulate ventricular pressure development.

• Research Organization: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
• Sponsoring Organization: USDOE
• OSTI ID: 1002388
• Journal Information: J. Mol. Cell. Cardiol., Journal Name: J. Mol. Cell. Cardiol. Journal Issue: (5) ; 05, 2010 Vol. 48
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS
HEART
MUSCLES
PROTEINS