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Title: Cysteine-containing peptides having antioxidant properties

Patent ·
OSTI ID:1001794
 [1]
  1. Castro Valley, CA
+ Show Author Affiliations

Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-I.sub.Milano (R173C) and apoA-I.sub.Paris, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The addition of a free thiol, at the hydrophobic/hydrophilic interface of an amphipathic alpha helix of synthetic peptides that mimic HDL-related proteins, imparts a unique antioxidant activity to these peptides which inhibits lipid peroxidation and protects phospholipids from water-soluble free radical initiators. These peptides can be used as therapeutic agents to combat cardiovascular disease, ischemia, bone disease and other inflammatory related diseases.

Research Organization:
Univ. of California (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,601,802
Application Number:
11/177,225
OSTI ID:
1001794
Country of Publication:
United States
Language:
English

References (23)

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60 APPLIED LIFE SCIENCES