Functionalized Nanoporous Silica for Removal of Heavy Metals from Biological Systems; Adsorption and Application

Journal Article · Fri Oct 01 04:00:00 EDT 2010 · ACS Applied Materials & Interfaces, 2(10):2749-2758

DOI:https://doi.org/10.1021/am100616b· OSTI ID:1000623

Yantasee, Wassana; Rutledge, Ryan D; Chouyyok, Wilaiwan; Sukwarotwat, Vichaya; Orr, Galya; Warner, Cynthia L; Warner, Marvin G; Fryxell, Glen E; Wiacek, Robert J; Timchalk, Charles; Addleman, Raymond S

Functionalized nanoporous silica, often referred to as self-assembled monolayers on mesoporous supports (SAMMS) have previously demonstrated the ability to serve as very effective heavy metal sorbents in a range of aquatic and environmental systems suggesting they may be advantageously utilized for biomedical applications such as chelation therapy. Herein we evaluate surface chemistries for heavy metal capture from biological fluids, various facets of the materials biocompatibility and the suitability of these materials as potential therapeutics. Of the materials tested, thiol-functionalized SAMMS proved most capable of removing selected heavy metals from biological solutions (i.e. blood, urine, etc.) As a result, thiol SAMMS was further analyzed to assess the material’s performance under a number of different biologically relevant conditions (i.e. variable pH and ionic strength) as well to gauge any potentially negative cellular effects resulting from interaction with the sorbent, such as cellular toxicity or possible chelation of essential minerals. Additionally, cellular uptake studies demonstrated no cell membrane permeation by the silica-based materials generally highlighting their ability to remain cellularly inert and thus non-toxic. As a result, it has been determined that organic ligand-functionalized nanoporous silica materials could be a valuable material for detoxification therapeutics and potentially other biomedical applications as needed.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1000623
• Report Number(s): PNNL-SA-73483; 30433; 400412000
• Journal Information: ACS Applied Materials & Interfaces, 2(10):2749-2758, Journal Name: ACS Applied Materials & Interfaces, 2(10):2749-2758 Journal Issue: 10 Vol. 2; ISSN XW7272; ISSN 1944-8244
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
ADSORPTION
BLOOD
CANCER
CELL MEMBRANES
DETOXIFICATION
DRUG-DELIVERY SYSTEM
DRUGS
Environmental Molecular Sciences Laboratory
HEAVY METALS
MCM-41
NANOPARTICLES
NATURAL-WATERS
PERFORMANCE
PORE-SIZE
REMOVAL
SAMMS
SELF-ASSEMBLED MONOLAYERS
SILICA
THERAPY
THIOLS
TOXICITY
URINE
biocompatibility
detoxification
heavy metal chelation
heavy-metal chelation
iminodiacetic acid
ion exchange
mesoporous
nanoporous
resin
sorbent
thiol