Paul D. Boyer, Adenosine Triphosphate (ATP), and the
Binding Change Mechanism
'For Paul Boyer, the Nobel Prize was "an unexpected pleasure." It had been 20 years since he formulated a hypothesis to describe what he calls "the most prominent chemical reaction in the whole world." It is the process by which molecules produce ATP (adenosine triphosphate), thereby transmuting light, air, water and food into the energy required for both plant and animal life.
Boyer had been greeted with disbelief when he theorized that the previously mysterious process is the work of a "beautiful little machine" that operates within enzymes on the molecular level. ...
Boyer experienced "one of the warmest moments of my life" when he learned that British biochemist John Walker had worked out the methodology required to demonstrate whether Boyer had been right or wrong. ... Using Walker's methodology, one of Boyer's former graduate students "did some elegant chemical work to demonstrate that the molecular rotation actually occurred." Boyer's hypothesis, finally, had been proven correct. For work that so enriched understanding of the life process itself, he and Walker were jointly awarded the Nobel prize [in Chemistry] in 1997.'
Additional information about Paul Boyer and adenosine triphosphate (APT) is available in documents and on the Web.
A Perspective of the Binding Change Mechanism for ATP Synthesis, The FASEB Journal, Vol 3, 2164-2178, 1989
Energy Capture and Use in Plants and Bacteria. Final Technical Report, DOE Technical Report, 1993
The ATP Synthase – A Splendid Molecular Machine, Annual Review of Biochemistry, Vol. 66: 717-749, 1997
Energy, Life, and ATP, Nobel Lecture, 1997, Bioscience Reports, Vol. 18, No. 3, 1998ATP Synthesis and the Binding Change Mechanism: The Work of Paul D. Boyer, The Journal of Biological Chemistry, Vol. 281, Issue 23, 18, 2006
of ATP Synthesis
Additional Web Pages:
Interview with Paul Boyer, nobelprize.org (video)
Patent: US 7,560,117; Foamy Virus Mutant Reverse Transcriptase