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Title: Acceleration Of Wound Healing Ny Photodynamic Therapy

Patent ·
OSTI ID:879214

Disclosed is a method for accelerating wound healing in a mammal. The method includes identifying an unhealed wound site or partially-healed wound site in a mammal; administering a photosensitizer to the mammal; waiting for a time period wherein the photosensitizer reaches an effective tissue concentration at the wound site; and photoactivating the photosensitizer at the wound site. The dose of photodynamic therapy is selected to stimulate the production of one or more growth factor by cells at the wound site, without causing tissue destruction.

Research Organization:
Massachusetts General Hospital
DOE Contract Number:
FG02-91ER61228
Assignee:
The General Hospital Corporation (Boston, MA)
Patent Number(s):
US 6107466
Application Number:
08/160528
OSTI ID:
879214
Country of Publication:
United States
Language:
English

References (32)

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Keratinocyte-Derived Vascular Permeability Factor (Vascular Endothelial Growth Factor) Is a Potent Mitogen for Dermal Microvascular Endothelial Cells journal July 1995
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In Vitro Assessment of the Biological Activity of Basic Fibroblast Growth Factor Released from Various Polymers and Biomatrices journal July 1997
Interactions between porphyrins and mitochondrial benzodiazepine receptors journal March 1988
METALLOPURPURINS and LIGHT: EFFECT ON TRANSPLANTABLE RAT BLADDER TUMORS and MURINE SKIN journal May 1990
Thalidomide as replacement for steroids in immunosuppression after lung transplantation journal February 1995
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Activation of mouse macrophages by in vivo and in vitro treatment with a cyanine dye, lumin journal May 1992
Aluminium β-Cyclodextrin Sulphate as a Stabilizer and Sustained-release Carrier for Basic Fibroblast Growth Factor journal March 1994

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