PCR thermocycler

Patent · Wed Jan 01 00:00:00 EST 2003

OSTI ID:874979

Benett, William J ^[1]; Richards, James B ^[2]

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1. Livermore, CA
2. Danville, CA

A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): US 6503750
• OSTI ID: 874979
• Country of Publication: United States
• Language: English

Related Subjects

pcr
thermocycler
sleeve-type
silicon
polymerase
chain
reaction
chamber
improved
thermal
performance
sleeve
etched
features
reduce
mass
increase
surface
cooling
enables
speed
efficiency
improvement
accomplished
providing
grooves
series
interior
surfaces
connect
anisotropically
simultaneously
formation
reaction chamber
interior surface
chain reaction
reduce thermal
thermal mass
thermal performance
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