VISTA - computational tools for comparative genomics
Comparison of DNA sequences from different species is a fundamental method for identifying functional elements in genomes. Here we describe the VISTA family of tools created to assist biologists in carrying out this task. Our first VISTA server at http://www-gsd.lbl.gov/VISTA/ was launched in the summer of 2000 and was designed to align long genomic sequences and visualize these alignments with associated functional annotations. Currently the VISTA site includes multiple comparative genomics tools and provides users with rich capabilities to browse pre-computed whole-genome alignments of large vertebrate genomes and other groups of organisms with VISTA Browser, submit their own sequences of interest to several VISTA servers for various types of comparative analysis, and obtain detailed comparative analysis results for a set of cardiovascular genes. We illustrate capabilities of the VISTA site by the analysis of a 180 kilobase (kb) interval on human chromosome 5 that encodes for the kinesin family member3A (KIF3A) protein.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director. Office of Science. Office of Biological andEnvironmental Research; National Institutes of Health. Department ofHealth and Human Services. National Heart Lung and BlookInstitute
- DOE Contract Number:
- DE-AC02-05CH11231
- OSTI ID:
- 860307
- Report Number(s):
- LBNL-54962; NARHAD; R&D Project: VGTLID; BnR: KP1102010; TRN: US200524%%81
- Journal Information:
- Nucleic Acids Research, Vol. 32; Related Information: Journal Publication Date: 07/2004; ISSN 0305-1048
- Country of Publication:
- United States
- Language:
- English
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