Human Genetic Marker for Resistance to Radiations and Chemicals

Technical Report · Tue Jun 01 00:00:00 EDT 1999

DOI:https://doi.org/10.2172/827386· OSTI ID:827386

Lieberman, Howard B

The major goal of the research project is to define the role of HRAD9 in the response of cells to radiation or chemical exposure, and to establish this gene as a genetic marker to predict predisposition to the deleterious health effects that may result after exposure to these agents. HRAD9 is a human homologue of fission yeast S. pombe rad9, a gene known to promote radioresistance and chemoresistance, and to regulate cell cycle progression after DNA is damaged or DNA replication is incomplete -i.e., it mediates cell cycle checkpoint control. Therefore, HRAD9 likely plays an important role in humans to determine the biological consequences of DNA damage.

• Research Organization: Columbia University, New York, New York (US)
• Sponsoring Organization: USDOE Office of Environmental Management (EM) (US)
• DOE Contract Number: FG07-96ER62309
• OSTI ID: 827386
• Report Number(s): EMSP-55100-1999; R&D Project: EMSP 55100; TRN: US200425%%633
• Resource Relation: Other Information: PBD: 1 Jun 1999
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
CELL CYCLE
DNA
DNA DAMAGES
DNA REPLICATION
FISSION
GENES
GENETICS
RADIATIONS
RADIOSENSITIVITY
YEASTS