Ames test mutagenicity studies of the subfractions of the mild gasification composite material, MG-120

Technical Report · Fri Apr 17 00:00:00 EDT 1992

DOI:https://doi.org/10.2172/7235721· OSTI ID:7235721

Mutagenicity of six mild gasification product samples was studied using the Ames Salmonella/microsomal assay system. The results of the Ames testing of the MG-119 and MG-120 subfractions indicate significant mutagenic activity only in the nonpolar neutral fraction. The activity was evident on bacterial strains, TA98 and TA100, with and without metabolic activation for MG-120, and with metabolic activation for MG-119. Previous testing of MG-119 and MG-120 when solvated in DMSO had shown possible, but unconfirmable, mutagenic activity. Tween 80-solvated MG-119 and MG-120 showed low, but significant, mutagenic activity only on TA98 with metabolic activation. Comparison of these results indicate an inhibition of the mutagenic components by nonmutagenic components in the complex mixture. 4 refs., 2 tabs.

• Research Organization: National Inst. for Occupational Safety and Health, Morgantown, WV (United States). Div. of Respiratory Disease Studies
• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AI21-89MC26018
• OSTI ID: 7235721
• Report Number(s): DOE/MC/26018-T15; ON: DE92017653
• Country of Publication: United States
• Language: English

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