Use of the power burst facility for boron neutron capture therapy

Conference · Sun Jan 01 00:00:00 EST 1989

OSTI ID:6882667

Crocker, J G; Griebenow, M L; Leatham, J

A program is under development at the Idaho National Engineering Laboratory (INEL) that involves using the Power Burst Facility (PBF) for research into Boron Neutron Capture Therapy (BNCT). BNCT utilizes the ionizing energy from boron-neutron capture to stop reproduction of or destroy cells in cancerous tissue in a two step process. The first step is to selectively concentrate a boron isotope within the tumor cell, that when activated by neutron capture emits highly ionizing, short range particles. The second step involves activation of the isotope only in the vicinity of the tumor with a narrow neutron beam. The INEL program includes the modification of the PBF by the addition of a neutron filter and treatment area. The intense source of epithermal neutrons from PBF is considered necessary to achieve optimum therapy for deep-seated tumors with minimum damage to surface tissue. The INEL program leads to human clinical trials at PBF which is intended to prove that brain tumors can be successfully treated through noninvasive techniques. Further research into BNCT at PBF for other cancer types is also anticipated. 9 refs., 4 figs.

• Research Organization: EG and G Idaho, Inc., Idaho Falls, ID (United States)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 6882667
• Report Number(s): EGG-M-89067; IAEA-SM-310/19; CONF-8910406-1; ON: DE90010955
• Resource Relation: Conference: International Atomic Energy Agency symposium, Ontario (Canada), 23-27 Oct 1989
• Country of Publication: United States
• Language: English

Related Subjects

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NEOPLASMS
NEUTRON CAPTURE THERAPY
PBF REACTOR
THERAPEUTIC USES
BIOLOGICAL EFFECTS
BORON 10 REACTIONS
CELL KILLING
EPITHERMAL NEUTRONS
IDAHO NATIONAL ENGINEERING LABORATORY
LET
RADIONUCLIDE KINETICS
THERMAL FISSION
THERMAL NEUTRONS
TUMOR CELLS
ANIMAL CELLS
BARYON REACTIONS
BARYONS
BODY
CENTRAL NERVOUS SYSTEM
CHARGED-PARTICLE REACTIONS
DISEASES
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
FISSION
HADRON REACTIONS
HADRONS
HEAVY ION REACTIONS
MEDICINE
NATIONAL ORGANIZATIONS
NERVOUS SYSTEM
NEUTRON REACTIONS
NEUTRON THERAPY
NEUTRONS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEON REACTIONS
NUCLEONS
ORGANS
PULSED REACTORS
RADIOLOGY
RADIOTHERAPY
REACTORS
TANK TYPE REACTORS
THERAPY
US DOE
US ERDA
US ORGANIZATIONS
USES
220600* - Nuclear Reactor Technology- Research
Test & Experimental Reactors
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)