Ultrastructural changes in the lung following exposure to perfluoroisobutylene (PFIB) and potentiation of PFIB-induced lung injury by post-exposure exercise
The authors investigated the kinetics of development of the injurious effects of perfluoroisobutylene (PFIB) in the lower respiratory tract of the rat as a function of inhaled mass concentration. We additionally examined if exercise performed after exposure to PFIB can potentiate the severity of expression of PFIB-induced lung injury, while also assessing how PFIB exposure may result in reductions in work performance capacity. The severity of PFIB-induced lung injury was found to be directly proportional to inhaled PFIB mass concentration whereas the post-exposure kinetics of development of the injurious response was inversely proportional to the mass concentration of PFIB, with post-exposure latency periods prior to the onset of detectable injury increasing with decreasing inhaled mass concentration. Exercise was found to potentiate PFIB-induced lung injury only after pulmonary edema was demonstrably present using lung gravimetric and light histopathologic criteria, even though ultrastructural observations indicated significant cellular changes occur during the latency period. Our collective findings suggest that pre-existing permeability changes in the lung are a necessary prerequisite for post-exposure exercise to exert a potentiating effect. Reductions in work performance capacity occurred only after the latency period, and such reductions proportionately scaled with the severity of pulmonary edema. 9 refs., 5 figs.
- Research Organization:
- Los Alamos National Lab., NM (USA)
- Sponsoring Organization:
- USDOD
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6268895
- Report Number(s):
- LA-UR-90-4261; CONF-9011164-1; ON: DE91005877
- Resource Relation:
- Conference: 1990 scientific conference on chemical defense research, Aberdeen Proving Ground, MD (USA), 14-18 Nov 1990
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LUNGS
ULTRASTRUCTURAL CHANGES
ORGANIC FLUORINE COMPOUNDS
TOXICITY
EXERCISE
INHALATION
RATS
ANIMALS
BODY
INTAKE
MAMMALS
MORPHOLOGICAL CHANGES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology