Nuclear resonance fluorescence: new technique for in vivo iron determination in man
A technique for the measurement of body iron stores utilizing nuclear resonant scattering of gamma-rays has been developed. 847keV photons emitted from a gaseous /sup 56/MnCl/sub 2/ source are resonantly scattered from /sup 56/Fe present in the liver and are detected by two large volume Ge(Li) detectors. Due to the very narrow resonance of the absorption cross section the technique is very specific to the element under investigation. The spatial uniformity of activation, the sensitivity of the detection system and the limits of detection have been investigated. Measurements were made of liver of a man-like phantom. The sensitivity and the limit of detection obtained for the NRS technique developed in this study are adequate for detection of iron in livers of normal individuals and are certainly sufficient for livers of persons with iron overload.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- EY-76-C-02-0016
- OSTI ID:
- 6255712
- Report Number(s):
- BNL-25699; CONF-790812-1; TRN: 79-016056
- Resource Relation:
- Conference: 5. international conference on medical physics, Jerusalem, Israel, 19 Aug 1979
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
IRON
CHEMICAL ANALYSIS
LIVER
EXPERIMENTAL DATA
FLUORESCENCE
GRAPHS
IN VIVO
IRON 56
MAN
MANGANESE 56
MEASURING METHODS
PHANTOMS
RADIATION DETECTORS
RESONANCE SCATTERING
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DATA
DATA FORMS
DIGESTIVE SYSTEM
ELEMENTS
EVEN-EVEN NUCLEI
GLANDS
HOURS LIVING RADIOISOTOPES
INELASTIC SCATTERING
INFORMATION
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPES
LUMINESCENCE
MAMMALS
MANGANESE ISOTOPES
MEASURING INSTRUMENTS
METALS
MOCKUP
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
SCATTERING
STABLE ISOTOPES
STRUCTURAL MODELS
TRANSITION ELEMENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400105 - Separation Procedures