Pathogenic mechanism in lung fibrosis. [Synergistic effects of BHT, O/sub 2/, and x rays in mice]

Conference · Mon Jan 01 00:00:00 EST 1979

OSTI ID:5616653

Witschi, H.; Haschek, W. M.; Meyer, K. R.; Ullrich, R. L.; Dalbey, W. E.

The purpose of the study was to examine whether an interaction between two agents causing alveolar epithelial damage would produce lung fibrosis. In mouse lung, intraperitoneal injection of the antioxidant butylated hydroxytoluene causes diffuse alveolar type I cell necrosis, followed by proliferation of type II alveolar cells. In animals exposed to 70% O/sub 2/ or 100-200 rad x rays during the phase of type II cell proliferation following BHT, diffuse interstitial lung fibrosis developed within 2 weeks. Quantitative analysis of the lungs for hydroxyproline showed that the interaction between BHT and O/sub 2/ or x rays was synergistic. If exposure to O/sub 2/ or x rays was delayed until epithelial recovery was complete, no fibrosis was seen. Abnormally high levels of lung collagen persisted up to 6 months after one single treatment with BHT and 100 rad x rays. A commonly seen form of chronic lung damage may thus be caused by an acute interaction between a bloodborne agent which damages the alveolar cell and a toxic inhalant or x rays, provided a critically ordered sequence of exposure is observed.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOE Environment and Safety
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5616653
• Report Number(s): CONF-790249-1; TRN: 80-005900
• Resource Relation: Conference: International conference on occupational lung disease, San Francisco, CA, USA, 27 Feb 1979
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIOXIDANTS
BIOLOGICAL EFFECTS
RADIOSENSITIVITY EFFECTS
BIOLOGICAL RECOVERY
FIBROSIS
RADIOINDUCTION
LUNGS
DELAYED RADIATION EFFECTS
OXYGEN
ACUTE IRRADIATION
CHEST
COLLAGEN
EXPERIMENTAL DATA
HYDROXYPROLINE
ISOLATED VALUES
LOCAL IRRADIATION
MICE
RESPIRATORY TRACT CELLS
SYNERGISM
TIME DEPENDENCE
X RADIATION
ACUTE EXPOSURE
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AZOLES
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CRYOGENIC FLUIDS
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NONMETALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
PYRROLES
PYRROLIDINES
RADIATION EFFECTS
RADIATIONS
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
VERTEBRATES
560100* - Biomedical Sciences
Applied Studies- Radiation Effects