Regional myocardial blood flow, metabolism and function assessed noninvasively by positron emission tomography
Positron emission computed tomography is a new technique for the noninvasive measure of myocardial blood flow, mechanical function and, in particular, metabolism. The capability of this new study means is due to the technological innovations of the imaging device and the availability of radioactive tracers that are specific for blood flow and metabolism. The device permits recording of cross-sectional images of the left ventricular myocardium that reflect quantitatively regional tracer tissue concentrations. By employing tracer kinetic models this new technique permits the measurement of regional glucose and fatty acid metabolism of the heart. While already an important new tool for investigative studies into cardiac physiology and pathophysiology, the clinical utility of positron emission tomography remains to be defined.
- Research Organization:
- California Univ., Los Angeles (USA). Lab. of Nuclear Medicine and Radiation Biology; California Univ., Los Angeles (USA). School of Medicine
- DOE Contract Number:
- EY-76-C-03-0012
- OSTI ID:
- 5612866
- Report Number(s):
- UCLA-12-1230; TRN: 80-004722
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD FLOW
MEASURING METHODS
CARBON 11
ECAT SCANNING
CARDIOVASCULAR DISEASES
DIAGNOSIS
FLUORINE 18
METABOLISM
MYOCARDIUM
DYNAMIC FUNCTION STUDIES
NITROGEN 13
OXYGEN 15
RADIOPHARMACEUTICALS
BIOLOGICAL LOCALIZATION
CARBOXYLIC ACIDS
GLUCOSE
PATIENTS
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBON ISOTOPES
CARDIOVASCULAR SYSTEM
CAT SCANNING
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MUSCLES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN ISOTOPES
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
RADIOACTIVE MATERIALS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques
550201 - Biochemistry- Tracer Techniques
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)