Kinetic analysis of dynamic PET data

Technical Report · Thu Dec 01 00:00:00 EST 1983

DOI:https://doi.org/10.2172/5178278· OSTI ID:5178278

Knittel, B

Our goal is to quantify regional physiological processes such as blood flow and metabolism by means of tracer kinetic modeling and positron emission tomography (PET). Compartmental models are one way of characterizing the behavior of tracers in physiological systems. This paper describes a general method of estimating compartmental model rate constants from measurements of the concentration of tracers in blood and tissue, taken at multiple time intervals. A computer program which applies the method is described, and examples are shown for simulated and actual data acquired from the Donner 280-Crystal Positron Tomograph.

• Research Organization: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 5178278
• Report Number(s): LBL-17313; ON: DE84008165
• Resource Relation: Other Information: Portions are illegible in microfiche products. Thesis
• Country of Publication: United States
• Language: English

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