Detection and analysis of polymerase chain reaction products by mass spectrometry
Conference
·
OSTI ID:486563
This paper describes recent and ongoing efforts to overcome some of the obstacles to more routine and robust application of MALDI-TOF to analysis of polymerase chain reaction products and other information- bearing nucleic acid molecules. Methods for purifying nucleic acid samples are described, as is the application of delayed extraction TOF mass spectrometry to analysis of short oligonucleotides.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE Assistant Secretary for Human Resources and Administration, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
- DOE Contract Number:
- AC05-96OR22464
- OSTI ID:
- 486563
- Report Number(s):
- CONF-970231-5; ON: DE97003085; CNN: Grant No. 1 R55 HG/OD00819-01A1
- Resource Relation:
- Conference: SPIE international symposium, San Jose, CA (United States), 8-14 Feb 1997; Other Information: PBD: 1997
- Country of Publication:
- United States
- Language:
- English
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