Electron Scattering from 1-Methyl-5-Nitroimidazole: Cross-Sections for Modeling Electron Transport through Potential Radiosensitizers
[1];
[2];
[3];
[4];
[5];
[8];
[8];
[9];
[10];
[11];
[12];
- Universidade NOVA de Lisboa (Portugal); Consejo Superior de Investigaciones Cientificas (CSIC), Madrid (Spain)
- Consejo Superior de Investigaciones Cientificas (CSIC), Madrid (Spain)
- Centre National de la Recherche Scientifique-Mixed Organizations (CNRS-UMR), Paris (France); Univ. of Toulouse (France)
- Universidad Complutense de Madrid (Spain)
- Research Centre for Energy, Environment and Technology (CIEMAT), Madrid (Spain)
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Univ. of Nebraska, Lincoln, NE (United States)
- Univ. of Nebraska, Lincoln, NE (United States)
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Max Planck Institute for Nuclear Physics, Heidelberg (Germany)
- Universidade NOVA de Lisboa (Portugal); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Universidade NOVA de Lisboa (Portugal)
- Universitario Ramón y Cajal, Madrid (Spain)
- Consejo Superior de Investigaciones Cientificas (CSIC), Madrid (Spain); Univ. of Wollongong, NSW (Australia)
In this study, we present a complete set of electron scattering cross-sections from 1-Methyl-5-Nitroimidazole (1M5NI) molecules for impact energies ranging from 0.1 to 1000 eV. This information is relevant to evaluate the potential role of 1M5NI as a molecular radiosensitizers. The total electron scattering cross-sections (TCS) that we previously measured with a magnetically confined electron transmission apparatus were considered as the reference values for the present analysis. Elastic scattering cross-sections were calculated by means of two different schemes: The Schwinger multichannel (SMC) method for the lower energies (below 15 eV) and the independent atom model-based screening-corrected additivity rule with interferences (IAM-SCARI) for higher energies (above 15 eV). The latter was also applied to calculate the total ionization cross-sections, which were complemented with experimental values of the induced cationic fragmentation by electron impact. Double differential ionization cross-sections were measured with a reaction microscope multi-particle coincidence spectrometer. Using a momentum imaging spectrometer, direct measurements of the anion fragment yields and kinetic energies by the dissociative electron attachment are also presented. Cross-sections for the other inelastic channels were derived with a self-consistent procedure by sampling their values at a given energy to ensure that the sum of the cross-sections of all the scattering processes available at that energy coincides with the corresponding TCS. This cross-section data set is ready to be used for modelling electron-induced radiation damage at the molecular level to biologically relevant media containing 1M5NI as a potential radiosensitizer. Nonetheless, a proper evaluation of its radiosensitizing effects would require further radiobiological experiments.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division (CSGB); Spanish Ministerio de Ciencia e Innovación; Spanish Ministerio de Universidades; Portuguese National Funding Agency
- Grant/Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1995988
- Journal Information:
- International Journal of Molecular Sciences (Online), Vol. 24, Issue 15; ISSN 1422-0067
- Publisher:
- MDPICopyright Statement
- Country of Publication:
- United States
- Language:
- English
Similar Records
Collisions of electrons with trimethylamine N(CH{sub 3}){sub 3} molecules
Low concentrations of nitroimidazoles: Effective radiosensitizers at low doses